Carolina Panthers vs San Francisco 49ers Match Player Stats (Nov 24, 2025)

Brock Purdy threw three interceptions before halftime. San Francisco won by eleven anyway.

Christian McCaffrey carried 24 times for 89 yards and caught seven passes for 53 more — 142 scrimmage yards in his first game against Carolina since the Panthers traded him in October 2022. His 12-yard touchdown run in the third quarter pushed the lead to 17-3 and ended any realistic chance of a Panthers comeback. The 49ers held Carolina to three points off Purdy’s three first-half turnovers and improved to 8-4, while the Panthers dropped to 6-6.

Purdy finished 23-of-32 for 193 yards with one touchdown and a 58.5 passer rating. Bryce Young went 18-of-29 for 169 yards and two interceptions — Carolina’s clearest path to a lead wiped out when safety Ji’Ayir Brown intercepted Young in the end zone with the Panthers at the 1-yard line in the second quarter.

Scoring Summary

San Francisco fed McCaffrey the ball on each of the opening drive’s first five plays, leading to the Purdy-to-Jennings score — the first opening-drive touchdown the Panthers allowed all season. Carolina was handed the ball inside the 49ers’ 30-yard line twice off Purdy’s first-half interceptions and produced three points. McMillan’s third-quarter touchdown came after a penalty on San Francisco pushed the two-point conversion attempt back to the 1-yard line; Young’s pass to Jalen Coker fell incomplete.

Passing Stats

Purdy was the first quarterback in the 2025 season to throw three interceptions in a single half. Cornerback Jaycee Horn picked him off twice before being ruled out in the third quarter with a concussion. Young entered the game off a 448-yard franchise-record performance at Atlanta the previous week — named NFC Offensive Player of the Week — but was restricted to 169 yards with two turnovers of his own. Entering Week 12, Purdy had thrown seven touchdowns and zero interceptions on all passes under 15 yards downfield, against one touchdown and seven interceptions on deeper throws.

Rushing Stats

San Francisco 49ers

Carolina Panthers

McCaffrey’s touchdown came on a toss sweep to the left end. It was his tenth 100-yard scrimmage game of the season, two short of the franchise record he set in 2023. Through 11 games entering Week 12, he had accumulated 707 rushing yards, 74 receptions, and 732 receiving yards.

Receiving Stats

San Francisco 49ers

Carolina Panthers

McMillan’s 29-yard touchdown catch was the longest play of the night for either side. It drew Carolina within eight at 17-9 before the failed two-point attempt left the Panthers needing two scores in the fourth quarter.

Defensive Stats

San Francisco 49ers Defense

Carolina Panthers Defense

Interceptions

Brown’s first interception came in the end zone after Young drove Carolina to the 1-yard line in the second quarter — a pick that immediately negated what would have been a go-ahead score. His second came at the San Francisco 33-yard line in the fourth quarter, ending the Panthers’ last meaningful drive with just over six minutes remaining. Horn’s two picks of Purdy set Carolina up with short fields — one was returned to the 49ers’ 16-yard line; the Panthers combined for three points off both turnovers.

Special Teams

Kicking

Gay was signed to replace Eddie Pineiro (hamstring), who had converted 22-of-22 field goals on the season entering Week 12.

Punting

Kick Returns

Punt Returns

Fumbles

Full Box Score — Team Stats

Injury Report — In-Game

Carolina Panthers: CB Jaycee Horn (concussion — ruled out, third quarter) | LB Claudin Cherelus (concussion — did not return) | G Chandler Zavala (calf — did not return) | CB Corey Thornton (ankle — did not return)

San Francisco 49ers: DE Sam Okuayinonu (ankle — did not return)

Safety Tre’Von Moehrig was subsequently suspended one game by the NFL for striking receiver Jauan Jennings in the groin late in the fourth quarter. The suspension was upheld on appeal.

Game Information

Officials

Carolina held a three-to-two edge in turnovers forced — meaning the Panthers won the turnover battle and still lost by eleven points. That margin comes down to what San Francisco’s defense did with the other side of the ledger: three points allowed off Purdy’s three first-half interceptions, two red zone trips held scoreless, and 230 total yards surrendered to an offense that had put up 448 passing yards seven days earlier. The box score made the 49ers look worse than the final score did; the defense made sure those numbers didn’t matter.